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You must use caution when driving, operating machinery, or engaging in hazardous activities when taking Solifenacin succinate to prevent injury to yourself and others. MANAGEMENT: Pharmacologic response to solifenacin should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the solifenacin dosage adjusted if necessary. According to the product labeling, coadministration of solifenacin (10 mg) with the potent CYP450 3A4 inhibitor ketoconazole (400 mg) resulted in a 1. Before taking Solifenacin succinate, make sure the doctor knows if you have liver or kidney disease, stomach or intestinal problems, severe constipation, eyes problems such as glaucoma, or a heart condition called prolonged QT interval. 5-fold increase in the mean solifenacin peak plasma concentration (Cmax) and a 2. 7-fold increase in the systemic exposure (AUC) compared to administration of solifenacin alone.

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